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A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity

Par un écrivain mystérieux

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A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
Discovery of Diverse CRISPR-Cas Systems and Expansion of the Genome Engineering Toolbox
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy, Molecular Cancer
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
PDF) A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
CRISPR/Cas9 On- and Off-Target Activity Using Correlative Force and Fluorescence Single-Molecule Microscopy
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
Interpretable neural architecture search and transfer learning for understanding CRISPR–Cas9 off-target enzymatic reactions
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
Insights into the Mechanism of CRISPR/Cas9-Based Genome Editing from Molecular Dynamics Simulations
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
Prediction of off-target effect and gRNA specificity with MOFF a A
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
A quantitative model for the dynamics of target recognition and off-target rejection by the CRISPR-Cas Cascade complex
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
Training on cleavage and binding for moderately mismatched targets a
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
CRISPR/Cas9 On- and Off-Target Activity Using Correlative Force and Fluorescence Single-Molecule Microscopy
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